De Bo Research Group
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Welcome to the
​De Bo group website

Our group is based in the Department of Chemistry of the University of Manchester. Our research focuses on the application of mechanical force in new synthetic process and on the creation of new mechanoresponsive molecular devices and materials.

A mechanochemical celebration of the University of Manchester bicentenary

Join us

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We have several opportunities for PhD students in synthetic and synthetic/computational mechanochemistry.
Check our Vacancies here.

Highlighted Research

Force-controlled release of small molecules with a rotaxane actuator
L. Chen, R. Nixon, and G. De Bo*
Nature 2024, 628, 320-325.
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Latest Research

A Mechanochromic Rotaxane that Releases Azetidine-Trityl-Maleimide, a Versatile Fluorescent Probe
M. Wu and G. De Bo*
Angew. Chem. Int. Ed. 2025, e202501499.
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Mechanochemical Generation of Aryne
Q. Cheng and G. De Bo*
Chem. Sci. 2024, 15, 13181–13184
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Latest News

Guillaume receives the 2025 ACS Macro journals Young Investigator Award!
Danny is now Dr Treacher!
MASC prizes for Rob and Lei!
Welcome to Oswald, Ronak, and Sevval!
Lei receives the Department Outstanding Achievement Award!
Rob receives the Faculty Best Outstanding Output Award!

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